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KMID : 1007520150240010273
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.273 ~ p.279
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Quercetin Ameliorates Insulin Sensitivity and Liver Steatosis Partly by Increasing Adiponectin Expression in ob/ob Mice
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Choi Ha-Neul
Jeong Soo-Mi
Huh Gyung-Hye
Kim Jung-In
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Abstract
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The effects of quercetin on non-alcoholic fatty liver disease (NAFLD) in an obese mouse model were investigated. Five-week-old ob/ob mice were fed an AIN- 93G diet or a diet containing 0.08% quercetin, whereas ob/+ mice were provided the AIN-93G diet for 10 weeks. Quercetin significantly decreased serum glucose, triglycerides, cholesterol, and free fatty acid (FFA) levels, and homeostasis model assessment for insulin resistance (HOMA-IR) values, compared with the ob/ob control group. Quercetin lowered hepatic total lipids, triglycerides, and cholesterol levels, and the serum alanine transaminase (ALT) activities, compared with the ob/ob control group. Quercetin increased adiponectin protein expression in epididymal adipose tissue and serum adiponectin levels, and decreased serum tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1), compared with the ob/ob control group. These results indicate that quercetin could exert protective effects against development of NAFLD, partly by overexpression of adiponectin and reduction of inflammatory cytokine levels in ob/ob mice.
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KEYWORD
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quercetin, adiponectin, steatosis, triglyceride, inflammation
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